HIV-1 infection influences NAD capping of some snRNA and snoRNA

We just published manuscript describing that HIV-1 infection negatively influences NAD capping in some snRNA and snoRNA. Particularly, we discovered that essential snRNA U1 is partially capped by NAD and the presence of this cap may impact the HIV-1 replication.

https://pubs.acs.org/doi/10.1021/acschembio.4c00151